Variation in the metagenomic analysis of fecal microbiome composition calls for a standardized operating approach

Variation in the metagenomic analysis of fecal microbiome composition calls for a standardized operating approach

ABSTRACT The reproducibility in microbiome studies is limited due to the lack of one gold-standard operating procedure. The aim of this study was to examine the impact of protocol variations on microbiome composition using metagenomic data sets from a single center. We assessed the variation in a da...

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Bibliographic Details
Main Authors: Zhilu Xu, Yun Kit Yeoh, Hein M. Tun, Na Fei, Jingwan Zhang, Mark Morrison, Michael A. Kamm, Jun Yu, Francis Ka Leung Chan, Siew C. Ng
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:Microbiology Spectrum
Subjects:
microbiome
metagenomics
DNA extraction
batch effect
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01516-24
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https://journals.asm.org/doi/10.1128/spectrum.01516-24

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