In vitro screening of UGT2B10 in silico prioritized putative ligands from drugs used in the pediatric hematopoietic stem cell transplantation setting

In vitro screening of UGT2B10 in silico prioritized putative ligands from drugs used in the pediatric hematopoietic stem cell transplantation setting

Abstract UGT2B10 is a phase II drug metabolizing enzyme with limited information on its role in the metabolism of drugs, especially in the pediatric hematopoietic stem cell transplantation setting. Previously, we investigated UGT2B10's role through in silico analyses and prioritized acetaminoph...

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Bibliographic Details
Main Authors: Yahia Bennani, Khalil Ben Hassine, Muhammed Gencaslan, Mary Boudal‐Khoshbeen, Caroline Samer, Marc Ansari, Youssef Daali, Chakradhara Rao Satyanarayana Uppugunduri
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Pharmacology Research & Perspectives
Subjects:
acetaminophen
glucuronidation
hematopoietic stem cell transplantation
lorazepam
mycophenolic acid
sinusoidal obstruction syndrome
Online Access:https://doi.org/10.1002/prp2.70011
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https://doi.org/10.1002/prp2.70011

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