Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke

Microglial NFAT5 aggravates neuroinflammation via mediating NLRP6 inflammasome in experimental ischemic stroke

Microglial activation triggers the inflammatory cascade and exacerbates brain injury following ischemic stroke. Middle cerebral artery occlusion (MCAO) modeling increased the expression of nuclear factor of activated T cells 5 (NFAT5) in microglia. However, the role of microglial NFAT5 in ischemic s...

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Bibliographic Details
Main Authors: Hui Gan, Mi Zhang, Yuhao Duan, Ailiyaer Palahati, Qi He, Junyi Tan, Yong Li, Xuan Zhai, Jing Zhao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Genes and Diseases
Subjects:
Ischemic stroke
Microglia
Neuroinflammation
NFAT5
NLRP6 inflammasome
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304225001035
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http://www.sciencedirect.com/science/article/pii/S2352304225001035

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