Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate

Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate

Abstract Background Tuberous sclerosis complex is a genetic disorder caused by mutations in the TSC1 or TSC2 genes, affecting multiple systems. These genes produce proteins that regulate mTORC1 activity, essential for cell function and metabolism. While mTOR inhibitors have advanced treatment, maint...

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Bibliographic Details
Main Authors: Shuang Wang, Ruishuang Ma, Chong Gao, Yu-Nong Tian, Rong-Gui Hu, Han Zhang, Lan Li, Yue Li
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Stem Cell Research & Therapy
Subjects:
Tuberous sclerosis complex
Mammalian target of rapamycin
Stem cell
Online Access:https://doi.org/10.1186/s13287-025-04170-3
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