Efficacy of cold and cryo-preserved nerve allografts with low-dose FK506 for motor nerve regeneration: a preclinical study

Efficacy of cold and cryo-preserved nerve allografts with low-dose FK506 for motor nerve regeneration: a preclinical study

Abstract Background Despite their ability to regenerate as well as autografts, the use of nerve allografts is limited by the need for immunosuppression and the risk of disease transmission. Further, decellularized allografts lacking Schwann cells limit axonal regeneration in long nerve defects. This...

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Bibliographic Details
Main Authors: Jong Pil Kim, Soon Chul Heo, Dae Hee Lee, Jun Sang Bae, Young Kwang Shin, Su Hyeok Son, Il Yong Park, Hae-Won Kim, Jun Hee Lee, Kyung Wook Kim
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Cryopreservation
Cold preservation
Allograft
Immunosuppression
Nerve reconstruction
FK506
Online Access:https://doi.org/10.1186/s13018-024-05343-1
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https://doi.org/10.1186/s13018-024-05343-1

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