Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method
Abstract Development of smart drug delivery systems (DDSs) for effective delivering drugs to targeted areas and achieving controlled drug release (CDR) is critical for cancer chemotherapy. The purpose of this study is synthesis of polydopamine (PDA) nanocapsules and analyze the adsorption and releas...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-01-01
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| Series: | Macromolecular Materials and Engineering |
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| Online Access: | https://doi.org/10.1002/mame.202400261 |
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| author | Elahe Abdollahi Vahid Haddadi‐Asl Hanie Ahmadi Mastoure Shirjandi Fatemeh Khanipour |
| author_facet | Elahe Abdollahi Vahid Haddadi‐Asl Hanie Ahmadi Mastoure Shirjandi Fatemeh Khanipour |
| author_sort | Elahe Abdollahi |
| collection | DOAJ |
| description | Abstract Development of smart drug delivery systems (DDSs) for effective delivering drugs to targeted areas and achieving controlled drug release (CDR) is critical for cancer chemotherapy. The purpose of this study is synthesis of polydopamine (PDA) nanocapsules and analyze the adsorption and release properties of doxorubicin (DOX). PDA nanocapsules are manufactured using hard template approach. The influence of various parameters such as pH, adsorption time, and initial DOX content on the adsorption and release process is investigated. The resulting adsorption isotherm is consistent with the Langmuir isotherm, indicating that DOX adsorption on PDA nanocapsules is homogenous, uniform, and monolayer. PDA nanocapsules have an adsorption capacity of 689.6 mg g−1 under alkaline conditions, which is attributed to phenol group deprotonation mechanism and electrostatic repulsion. The adsorption kinetics are more consistent with the pseudo‐second‐order model. Furthermore, raising initial concentration of DOX results in a greatly increased adsorption capacity due to a larger driving force. Among the several parameters that can influence the pace and degree of DOX loading and release, local pH is regarded as a significant environmental component in the processes. Thus, pH‐responsive PDA nanocapsules have a significant potential for usage in locations with aberrant pH level, such as cancer tissue. |
| format | Article |
| id | doaj-art-2328a354325e494792470c31d04a9219 |
| institution | Kabale University |
| issn | 1438-7492 1439-2054 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Macromolecular Materials and Engineering |
| spelling | doaj-art-2328a354325e494792470c31d04a92192025-01-13T15:24:25ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542025-01-013101n/an/a10.1002/mame.202400261Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template MethodElahe Abdollahi0Vahid Haddadi‐Asl1Hanie Ahmadi2Mastoure Shirjandi3Fatemeh Khanipour4Department of Polymer Engineering and Color Technology Amirkabir University of Technology P.O. Box Tehran 15875‐4413 IranDepartment of Polymer Engineering and Color Technology Amirkabir University of Technology P.O. Box Tehran 15875‐4413 IranDepartment of Polymer Engineering and Color Technology Amirkabir University of Technology P.O. Box Tehran 15875‐4413 IranDepartment of Polymer Engineering and Color Technology Amirkabir University of Technology P.O. Box Tehran 15875‐4413 IranDepartment of Polymer Engineering and Color Technology Amirkabir University of Technology P.O. Box Tehran 15875‐4413 IranAbstract Development of smart drug delivery systems (DDSs) for effective delivering drugs to targeted areas and achieving controlled drug release (CDR) is critical for cancer chemotherapy. The purpose of this study is synthesis of polydopamine (PDA) nanocapsules and analyze the adsorption and release properties of doxorubicin (DOX). PDA nanocapsules are manufactured using hard template approach. The influence of various parameters such as pH, adsorption time, and initial DOX content on the adsorption and release process is investigated. The resulting adsorption isotherm is consistent with the Langmuir isotherm, indicating that DOX adsorption on PDA nanocapsules is homogenous, uniform, and monolayer. PDA nanocapsules have an adsorption capacity of 689.6 mg g−1 under alkaline conditions, which is attributed to phenol group deprotonation mechanism and electrostatic repulsion. The adsorption kinetics are more consistent with the pseudo‐second‐order model. Furthermore, raising initial concentration of DOX results in a greatly increased adsorption capacity due to a larger driving force. Among the several parameters that can influence the pace and degree of DOX loading and release, local pH is regarded as a significant environmental component in the processes. Thus, pH‐responsive PDA nanocapsules have a significant potential for usage in locations with aberrant pH level, such as cancer tissue.https://doi.org/10.1002/mame.202400261doxorubicindrug deliveryencapsulationpolydopamine |
| spellingShingle | Elahe Abdollahi Vahid Haddadi‐Asl Hanie Ahmadi Mastoure Shirjandi Fatemeh Khanipour Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method Macromolecular Materials and Engineering doxorubicin drug delivery encapsulation polydopamine |
| title | Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method |
| title_full | Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method |
| title_fullStr | Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method |
| title_full_unstemmed | Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method |
| title_short | Investigation of Release Kinetics of DOX from Polydopamine Nanocapsules Prepared by Hard Template Method |
| title_sort | investigation of release kinetics of dox from polydopamine nanocapsules prepared by hard template method |
| topic | doxorubicin drug delivery encapsulation polydopamine |
| url | https://doi.org/10.1002/mame.202400261 |
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