Reversal gene expression assessment for drug repurposing, a case study of glioblastoma

Reversal gene expression assessment for drug repurposing, a case study of glioblastoma

Abstract Background Glioblastoma (GBM) is a rare brain cancer with an exceptionally high mortality rate, which illustrates the pressing demand for more effective therapeutic options. Despite considerable research efforts on GBM, its underlying biological mechanisms remain unclear. Furthermore, none...

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Bibliographic Details
Main Authors: Shixue Sun, Zeenat Shyr, Kathleen McDaniel, Yuhong Fang, Dingyin Tao, Catherine Z. Chen, Wei Zheng, Qian Zhu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
Rare diseases
Drug repurposing
Glioblastoma
Multi-omics analysis
Reversal gene expression
Online Access:https://doi.org/10.1186/s12967-024-06046-1
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