3D variability analysis reveals a hidden conformational change controlling ammonia transport in human asparagine synthetase

3D variability analysis reveals a hidden conformational change controlling ammonia transport in human asparagine synthetase

Abstract Advances in X-ray crystallography and cryogenic electron microscopy (cryo-EM) offer the promise of elucidating functionally relevant conformational changes that are not easily studied by other biophysical methods. Here we show that 3D variability analysis (3DVA) of the cryo-EM map for wild-...

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Main Authors: Adriana Coricello, Alanya J. Nardone, Antonio Lupia, Carmen Gratteri, Matthijn Vos, Vincent Chaptal, Stefano Alcaro, Wen Zhu, Yuichiro Takagi, Nigel G. J. Richards
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54912-9
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https://doi.org/10.1038/s41467-024-54912-9

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