Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case report

Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case report

Abstract Background Anti-centromere antibodies are autoantibodies that selectively bind to the centromere region of chromosomes. Studies have indicated that anti-centromere antibodies can induce microvascular alterations and tissue remodeling, ultimately leading to fibrosis. They have been implicate...

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Main Authors: Yuya Ando, Suguru Mabuchi, Norikazu Mataki, Satoshi Nakayama, Arata Honda, Mari Kamiya, Shinsuke Yasuda, Hiroaki Takeo, Shigeaki Aono, Masayoshi Hashimoto, Kenichi Harada, Naoya Murashima
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Medical Case Reports
Subjects:
Anti-centromere antibody
Idiopathic portal hypertension
Primary biliary cholangitis
Vascular endothelial dysfunction
Intrapapillary capillary loop
Nail capillary microscopy
Online Access:https://doi.org/10.1186/s13256-025-05426-5
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https://doi.org/10.1186/s13256-025-05426-5

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