Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health
Chronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted reproductive technologies such as in vitro fertilization (IVF). An essential component of innate immunity, the NLR family pyrin domain-conta...
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2025-01-01
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| author | Efthalia Moustakli Sofoklis Stavros Periklis Katopodis Charikleia Skentou Anastasios Potiris Periklis Panagopoulos Ekaterini Domali Ioannis Arkoulis Theodoros Karampitsakos Eleftheria Sarafi Theologos M. Michaelidis Athanasios Zachariou Athanasios Zikopoulos |
| author_facet | Efthalia Moustakli Sofoklis Stavros Periklis Katopodis Charikleia Skentou Anastasios Potiris Periklis Panagopoulos Ekaterini Domali Ioannis Arkoulis Theodoros Karampitsakos Eleftheria Sarafi Theologos M. Michaelidis Athanasios Zachariou Athanasios Zikopoulos |
| author_sort | Efthalia Moustakli |
| collection | DOAJ |
| description | Chronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted reproductive technologies such as in vitro fertilization (IVF). An essential component of innate immunity, the NLR family pyrin domain-containing 3 (NLRP3) inflammasome is one of the major mediators of inflammatory responses, and its activation is closely linked to oxidative stress. This interaction contributes to a decline in oocyte quality, reduced fertilization potential, and impaired embryo development. In the ovarian milieu, oxidative stress and NLRP3 inflammasome activation interact intricately, and their combined effects on oocyte competence and reproductive outcomes are significant. The aims of this review are to examine these molecular mechanisms and to explore therapeutic strategies targeting oxidative stress and NLRP3 inflammasome activity, with the goal of enhancing female fertility and improving clinical outcomes in reproductive health. |
| format | Article |
| id | doaj-art-222c00e4d31f4314adbbaf33fe372676 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-222c00e4d31f4314adbbaf33fe3726762025-01-10T13:16:19ZengMDPI AGCells2073-44092025-01-011413610.3390/cells14010036Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive HealthEfthalia Moustakli0Sofoklis Stavros1Periklis Katopodis2Charikleia Skentou3Anastasios Potiris4Periklis Panagopoulos5Ekaterini Domali6Ioannis Arkoulis7Theodoros Karampitsakos8Eleftheria Sarafi9Theologos M. Michaelidis10Athanasios Zachariou11Athanasios Zikopoulos12Laboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceLaboratory of Medical Genetics, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Obstetrics and Gynecology, Medical School of Ioannina, University General Hospital, 45110 Ioannina, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceFirst Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Biological Applications & Technology, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Biological Applications & Technology, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Urology, School of Medicine, University of Ioannina, 45110 Ioannina, GreeceThird Department of Obstetrics and Gynecology, University General Hospital “ATTIKON”, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceChronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted reproductive technologies such as in vitro fertilization (IVF). An essential component of innate immunity, the NLR family pyrin domain-containing 3 (NLRP3) inflammasome is one of the major mediators of inflammatory responses, and its activation is closely linked to oxidative stress. This interaction contributes to a decline in oocyte quality, reduced fertilization potential, and impaired embryo development. In the ovarian milieu, oxidative stress and NLRP3 inflammasome activation interact intricately, and their combined effects on oocyte competence and reproductive outcomes are significant. The aims of this review are to examine these molecular mechanisms and to explore therapeutic strategies targeting oxidative stress and NLRP3 inflammasome activity, with the goal of enhancing female fertility and improving clinical outcomes in reproductive health.https://www.mdpi.com/2073-4409/14/1/36inflammation pathwaysfertilization potentialredox balanceovarian agingmitochondria dysfunctioncytokine signaling |
| spellingShingle | Efthalia Moustakli Sofoklis Stavros Periklis Katopodis Charikleia Skentou Anastasios Potiris Periklis Panagopoulos Ekaterini Domali Ioannis Arkoulis Theodoros Karampitsakos Eleftheria Sarafi Theologos M. Michaelidis Athanasios Zachariou Athanasios Zikopoulos Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health Cells inflammation pathways fertilization potential redox balance ovarian aging mitochondria dysfunction cytokine signaling |
| title | Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health |
| title_full | Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health |
| title_fullStr | Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health |
| title_full_unstemmed | Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health |
| title_short | Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health |
| title_sort | oxidative stress and the nlrp3 inflammasome focus on female fertility and reproductive health |
| topic | inflammation pathways fertilization potential redox balance ovarian aging mitochondria dysfunction cytokine signaling |
| url | https://www.mdpi.com/2073-4409/14/1/36 |
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