The clinical utility of bronchoalveolar lavage fluid metagenomic next-generation sequencing in immunocompromised critically ill patients with invasive pulmonary aspergillosis: a multicenter retrospective study

The clinical utility of bronchoalveolar lavage fluid metagenomic next-generation sequencing in immunocompromised critically ill patients with invasive pulmonary aspergillosis: a multicenter retrospective study

ABSTRACT The clinical utility of metagenomic next-generation sequencing (mNGS) in immunocompromised critically ill patients with invasive pulmonary aspergillosis (IPA) remains poorly studied. Given the diagnostic challenges and high mortality associated with IPA in this population, further research...

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Main Authors: Junjie Zhao, Runxi Zhuge, Kai Guo, Jing Tang, Yong Sun, Yi Zhang, Lingmin Yuan, Canhu Qiu, Youqin Yan, Kaiyu Wang, Qin Jiang, Juan Chen, Zhidan Hua, Liyan Qiu, Honglong Fang, Jiancheng Zhuge
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
etiology
immunocompromised patients
bronchoalveolar lavage fluid
invasive pulmonary aspergillosis
metagenomic next-generation sequencing
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00584-25
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https://journals.asm.org/doi/10.1128/spectrum.00584-25

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