Comprehensive analysis of the prognostic, immunological, and diagnostic roles of SIRT1 in pan-cancer and its validation in KIRC

Comprehensive analysis of the prognostic, immunological, and diagnostic roles of SIRT1 in pan-cancer and its validation in KIRC

BackgroundDisturbances in DNA damage repair may lead to cancer. SIRT1, an NAD+-dependent deacetylase, plays a crucial role in maintaining cellular homeostasis through the regulation of processes such as histone posttranslational modifications, DNA repair, and cellular metabolism. However, a comprehe...

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Bibliographic Details
Main Authors: Qi Liu, Songxian Sun, Chunxiang Zhou, Houxi Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
SIRT1
pan-cancer
immunity
prognosis
biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501867/full
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