Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder
Abstract Isolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies. Using positron emission tomography, we assessed changes in Parkinson’s disease-related motor and cognitive metabolic networks and caudate/putamen dopaminergic input in a 4-year longitudinal imaging stu...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-12-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54695-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559267541254144 |
|---|---|
| author | Chris C. Tang Yoshikazu Nakano An Vo Nha Nguyen Katharina A. Schindlbeck Paul J. Mattis Kathleen L. Poston Jean-François Gagnon Ronald B. Postuma Martin Niethammer Yilong Ma Shichun Peng Vijay Dhawan David Eidelberg |
| author_facet | Chris C. Tang Yoshikazu Nakano An Vo Nha Nguyen Katharina A. Schindlbeck Paul J. Mattis Kathleen L. Poston Jean-François Gagnon Ronald B. Postuma Martin Niethammer Yilong Ma Shichun Peng Vijay Dhawan David Eidelberg |
| author_sort | Chris C. Tang |
| collection | DOAJ |
| description | Abstract Isolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies. Using positron emission tomography, we assessed changes in Parkinson’s disease-related motor and cognitive metabolic networks and caudate/putamen dopaminergic input in a 4-year longitudinal imaging study of 13 male subjects with this disorder. We also correlated times to phenoconversion with baseline network expression in an independent validation sample. Expression values of both Parkinson’s disease-related networks increased over time while dopaminergic input gradually declined in the longitudinal cohort. While abnormal functional connections were identified at baseline in both networks, others bridging these networks appeared later. These changes resulted in compromised information flow through the networks years before phenoconversion. We noted an inverse correlation between baseline network expression and times to phenoconversion to Parkinson’s disease or dementia with Lewy bodies in the validation sample. Here, we show that the rate of network progression is a useful outcome measure in disease modification trials. |
| format | Article |
| id | doaj-art-20c2a84870284749a16adedc0a31cb58 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-20c2a84870284749a16adedc0a31cb582025-01-05T12:36:24ZengNature PortfolioNature Communications2041-17232024-12-0115111210.1038/s41467-024-54695-zLongitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorderChris C. Tang0Yoshikazu Nakano1An Vo2Nha Nguyen3Katharina A. Schindlbeck4Paul J. Mattis5Kathleen L. Poston6Jean-François Gagnon7Ronald B. Postuma8Martin Niethammer9Yilong Ma10Shichun Peng11Vijay Dhawan12David Eidelberg13Center for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineCentre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de MontréalCentre d’Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de MontréalCenter for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchCenter for Neurosciences, The Feinstein Institutes for Medical ResearchAbstract Isolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies. Using positron emission tomography, we assessed changes in Parkinson’s disease-related motor and cognitive metabolic networks and caudate/putamen dopaminergic input in a 4-year longitudinal imaging study of 13 male subjects with this disorder. We also correlated times to phenoconversion with baseline network expression in an independent validation sample. Expression values of both Parkinson’s disease-related networks increased over time while dopaminergic input gradually declined in the longitudinal cohort. While abnormal functional connections were identified at baseline in both networks, others bridging these networks appeared later. These changes resulted in compromised information flow through the networks years before phenoconversion. We noted an inverse correlation between baseline network expression and times to phenoconversion to Parkinson’s disease or dementia with Lewy bodies in the validation sample. Here, we show that the rate of network progression is a useful outcome measure in disease modification trials.https://doi.org/10.1038/s41467-024-54695-z |
| spellingShingle | Chris C. Tang Yoshikazu Nakano An Vo Nha Nguyen Katharina A. Schindlbeck Paul J. Mattis Kathleen L. Poston Jean-François Gagnon Ronald B. Postuma Martin Niethammer Yilong Ma Shichun Peng Vijay Dhawan David Eidelberg Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder Nature Communications |
| title | Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder |
| title_full | Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder |
| title_fullStr | Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder |
| title_full_unstemmed | Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder |
| title_short | Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder |
| title_sort | longitudinal network changes and phenoconversion risk in isolated rem sleep behavior disorder |
| url | https://doi.org/10.1038/s41467-024-54695-z |
| work_keys_str_mv | AT chrisctang longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT yoshikazunakano longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT anvo longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT nhanguyen longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT katharinaaschindlbeck longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT pauljmattis longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT kathleenlposton longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT jeanfrancoisgagnon longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT ronaldbpostuma longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT martinniethammer longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT yilongma longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT shichunpeng longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT vijaydhawan longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder AT davideidelberg longitudinalnetworkchangesandphenoconversionriskinisolatedremsleepbehaviordisorder |