Estrogen protects against postpartum Concanavalin A-induced hepatitis by promoting intrahepatic CD4⁺CD25⁺ Treg expansion through activation of the PI3K/Akt signaling pathway in HBV-Tg mice

Estrogen protects against postpartum Concanavalin A-induced hepatitis by promoting intrahepatic CD4⁺CD25⁺ Treg expansion through activation of the PI3K/Akt signaling pathway in HBV-Tg mice

Abstract Introduction Postpartum hepatitis flares have been commonly described, but the specific mechanism is unclear. Objectives Our objective was to explore estrogen’s role in postpartum hepatitis flares in HBV transgenic mice. Methods The numbers of intrahepatic CD4+CD25+Foxp3+ regulatory T cells...

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Bibliographic Details
Main Authors: Chuanlu Xu, Yao Su, Wenjing Lu, Jiaqi Dong, Luyao Wang, Yabing Mi, Xinrui Jia, Wenqi Lv, Shengyu Wu, Yuanhui Jia, Hao Ying
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Virology Journal
Subjects:
Acute liver injury
Hepatitis B virus
Hepatitis B flares
Online Access:https://doi.org/10.1186/s12985-025-02879-4
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https://doi.org/10.1186/s12985-025-02879-4

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