Causal links of human serum metabolites on the risk of prostate cancer: insights from genome-wide Mendelian randomization, single-cell RNA sequencing, and metabolic pathway analysis

Causal links of human serum metabolites on the risk of prostate cancer: insights from genome-wide Mendelian randomization, single-cell RNA sequencing, and metabolic pathway analysis

BackgroundRecently, serum metabolites have shown potential in predicting survival outcomes and may be related to the pathogenesis of prostate cancer. Nevertheless, the precise impact concerning the genetic effect of metabolites on prostate cancer risk remains obscure. In this context, we conducted a...

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Bibliographic Details
Main Authors: Renbing Pan, Jingwen Liu, Mingjia Xiao, Chuanyang Sun, Jianyong Zhu, Lijun Wan, Boxin Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Endocrinology
Subjects:
serum metabolites
prostate cancer
Mendelian randomization
single-cell RNA-seq
metabolic pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1443330/full
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https://www.frontiersin.org/articles/10.3389/fendo.2024.1443330/full

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