Abnormal gut microbiota may cause PD-1 inhibitor-related cardiotoxicity via suppressing regulatory T cells

Abnormal gut microbiota may cause PD-1 inhibitor-related cardiotoxicity via suppressing regulatory T cells

Abstract Treatment with PD-1 inhibitors may cause immune-related adverse events (irAE), of which PD-1 inhibitor-associated myocarditis is a rare and highly lethal irAE. However, the mechanism of PD-1 inhibitors-induced myocarditis in individuals with tumor is still unclear. Regulatory T cells (Treg)...

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Bibliographic Details
Main Authors: Huili Cao, Huwei Dai, Songshan Li, Zeeshan Afzal, Xinyan Wang, Zeyu Wen, Kaiyong Xiao, Yajing Zhao, Jin Li, Bin Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Immune checkpoint inhibitors
Myocarditis
Regulatory T cell
Gut microbiota
Online Access:https://doi.org/10.1038/s41598-025-05635-4
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https://doi.org/10.1038/s41598-025-05635-4

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