GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis

GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis

Background & Aims: Cellular senescence is characterized by the loss of proliferative capacity, cell cycle arrest, and the acquisition of a proinflammatory senescence-associated secretory phenotype (SASP). Senescence is frequently present in advanced chronic liver diseases; however, the impac...

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Main Authors: Teresa Rubio-Tomás, David Martí-Aguado, Delia Blaya, Silvia Ariño, Beatriz Aguilar-Bravo, Raquel A. Martínez García de la Torre, Marc Miravet-Marti, Raquel Ferrer-Lorente, Laura Zanatto, Zengqing Xu, Laura Garcia-Tercero, Carlos Mateos-Sánchez, Juan José Lozano, Isabella Dotti, Johanne Poisson, Marion Tanguy, Azucena Salas, Pierre-Emmanuel Rautou, Ramon Bataller, Pau Sancho-Bru
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:JHEP Reports
Subjects:
alcohol-related liver disease
alcohol-associated hepatitis
senescence
GDF15
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925001569
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