Conformational control of the binding of the transactivation domain of the MLL protein and c-Myb to the KIX domain of CREB.

Conformational control of the binding of the transactivation domain of the MLL protein and c-Myb to the KIX domain of CREB.

The KIX domain of CBP is a transcriptional coactivator. Concomitant binding to the activation domain of proto-oncogene protein c-Myb and the transactivation domain of the trithorax group protein mixed lineage leukemia (MLL) transcription factor lead to the biologically active ternary MLL∶KIX∶c-Myb c...

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Bibliographic Details
Main Authors: Elif Nihal Korkmaz, Ruth Nussinov, Türkan Haliloğlu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002420&type=printable
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