Lysyl Oxidase Mediates Proliferation and Differentiation in the Esophageal Epithelium

Lysyl Oxidase Mediates Proliferation and Differentiation in the Esophageal Epithelium

In homeostatic conditions, the basal progenitor cells of the esophagus differentiate into a stratified squamous epithelium. However, in the setting of acid exposure or inflammation, there is a marked failure of basal cell differentiation, leading to basal cell hyperplasia. We have previously shown t...

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Bibliographic Details
Main Authors: Kanak V. Kennedy, Joshua X. Wang, Emily McMillan, Yusen Zhou, Ryugo Teranishi, Ann Semeao, Leena Mirchandani, Chizoba N. Umeweni, Diya Dhakal, Alyssa Baccarella, Satoshi Ishikawa, Masaru Sasaki, Takefumi Itami, Adele C. Harman, Leonel Joannas, Tatiana A. Karakasheva, Hiroshi Nakagawa, Amanda B. Muir
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
lysyl oxidase
esophagus
epithelial homeostasis
proliferation
differentiation
Online Access:https://www.mdpi.com/2218-273X/14/12/1560
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