In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants.

In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants.

SARS-CoV-2 has undergone repeated and rapid evolution to circumvent host immunity. However, outside of prolonged infections in immunocompromised hosts, within-host positive selection has rarely been detected. Here we combine daily longitudinal sampling of individuals with replicate sequencing to inc...

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Main Authors: Emily E Bendall, Derek Dimcheff, Leigh Papalambros, William J Fitzsimmons, Yuwei Zhu, Jonathan Schmitz, Natasha Halasa, James Chappell, Emily T Martin, Jessica E Biddle, Sarah E Smith-Jeffcoat, Melissa A Rolfes, Alexandra Mellis, H Keipp Talbot, Carlos Grijalva, Adam S Lauring
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013134
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https://doi.org/10.1371/journal.ppat.1013134

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