Gene editing and CRISPR-dependent homology-mediated end joining

Abstract Gene editing is the intentional modification of a genetic locus in a living cell and is used for two general applications of great importance and wide interest. One is the inactivation of genes (‘knockouts’), a process utilized to delineate the loss-of-function phenotype(s) of a particular...

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Bibliographic Details
Main Authors: Brian L. Ruis, Anja K. Bielinsky, Eric A. Hendrickson
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01442-z
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