Clinical significance of lipid pathway-targeted therapy in breast cancer
Globally, breast cancer represents the most common cancer and the primary cause of death by cancer in women. Lipids are crucial in human physiology, serving as vital energy reserves, structural elements of biological membranes, and essential signaling molecules. The metabolic reprogramming of lipid...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1514811/full |
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| author | Dan Li Dan Li Pengcheng Jin Yiqi Cai Yiqi Cai Shijie Wu Shijie Wu Xianan Guo Xianan Guo Zhiyun Zhang Zhiyun Zhang Kexin Liu Kexin Liu Panni Li Panni Li Yue Hu Yunxiang Zhou Yunxiang Zhou |
| author_facet | Dan Li Dan Li Pengcheng Jin Yiqi Cai Yiqi Cai Shijie Wu Shijie Wu Xianan Guo Xianan Guo Zhiyun Zhang Zhiyun Zhang Kexin Liu Kexin Liu Panni Li Panni Li Yue Hu Yunxiang Zhou Yunxiang Zhou |
| author_sort | Dan Li |
| collection | DOAJ |
| description | Globally, breast cancer represents the most common cancer and the primary cause of death by cancer in women. Lipids are crucial in human physiology, serving as vital energy reserves, structural elements of biological membranes, and essential signaling molecules. The metabolic reprogramming of lipid pathways has emerged as a critical factor in breast cancer progression, drug resistance, and patient prognosis. In this study, we delve into the clinical implications of lipid pathway-targeted therapy in breast cancer. We highlight key enzymes and potential therapeutic targets involved in lipid metabolism reprogramming, and their associations with cancer progression and treatment outcomes. Furthermore, we detail the clinical trials exploring the anticancer and cancer chemopreventive activity of therapies targeting these molecules. However, the clinical efficacy of these therapies remains controversial, highlighting the urgent need for predictive biomarkers to identify patient subpopulations likely to benefit from such treatment. We propose the Selective Lipid Metabolism Therapy Benefit Hypothesis, emphasizing the importance of personalized medicine in optimizing lipid pathway-targeted therapy for breast cancer patients. |
| format | Article |
| id | doaj-art-1f1205c47e3646e89eefad43c7b15890 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-1f1205c47e3646e89eefad43c7b158902025-01-06T06:59:17ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15148111514811Clinical significance of lipid pathway-targeted therapy in breast cancerDan Li0Dan Li1Pengcheng Jin2Yiqi Cai3Yiqi Cai4Shijie Wu5Shijie Wu6Xianan Guo7Xianan Guo8Zhiyun Zhang9Zhiyun Zhang10Kexin Liu11Kexin Liu12Panni Li13Panni Li14Yue Hu15Yunxiang Zhou16Yunxiang Zhou17Department of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Surgical Oncology, Linhai Branch, The Second Affiliated Hospital, Zhejiang University School of Medicine, Taizhou, Zhejiang, ChinaDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaGlobally, breast cancer represents the most common cancer and the primary cause of death by cancer in women. Lipids are crucial in human physiology, serving as vital energy reserves, structural elements of biological membranes, and essential signaling molecules. The metabolic reprogramming of lipid pathways has emerged as a critical factor in breast cancer progression, drug resistance, and patient prognosis. In this study, we delve into the clinical implications of lipid pathway-targeted therapy in breast cancer. We highlight key enzymes and potential therapeutic targets involved in lipid metabolism reprogramming, and their associations with cancer progression and treatment outcomes. Furthermore, we detail the clinical trials exploring the anticancer and cancer chemopreventive activity of therapies targeting these molecules. However, the clinical efficacy of these therapies remains controversial, highlighting the urgent need for predictive biomarkers to identify patient subpopulations likely to benefit from such treatment. We propose the Selective Lipid Metabolism Therapy Benefit Hypothesis, emphasizing the importance of personalized medicine in optimizing lipid pathway-targeted therapy for breast cancer patients.https://www.frontiersin.org/articles/10.3389/fphar.2024.1514811/fullbreast cancerlipid metabolism reprogrammingclinical trialtargeted therapypredictive biomarkershypothesis |
| spellingShingle | Dan Li Dan Li Pengcheng Jin Yiqi Cai Yiqi Cai Shijie Wu Shijie Wu Xianan Guo Xianan Guo Zhiyun Zhang Zhiyun Zhang Kexin Liu Kexin Liu Panni Li Panni Li Yue Hu Yunxiang Zhou Yunxiang Zhou Clinical significance of lipid pathway-targeted therapy in breast cancer Frontiers in Pharmacology breast cancer lipid metabolism reprogramming clinical trial targeted therapy predictive biomarkers hypothesis |
| title | Clinical significance of lipid pathway-targeted therapy in breast cancer |
| title_full | Clinical significance of lipid pathway-targeted therapy in breast cancer |
| title_fullStr | Clinical significance of lipid pathway-targeted therapy in breast cancer |
| title_full_unstemmed | Clinical significance of lipid pathway-targeted therapy in breast cancer |
| title_short | Clinical significance of lipid pathway-targeted therapy in breast cancer |
| title_sort | clinical significance of lipid pathway targeted therapy in breast cancer |
| topic | breast cancer lipid metabolism reprogramming clinical trial targeted therapy predictive biomarkers hypothesis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1514811/full |
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