An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins with both proinflammatory and immunoregulatory functions. TNF is a key mediator in autoimmune diseases and during the last couple of decades several biologic drugs have delivered new therapeutic options...

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Main Authors: Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
TNF
rheumatoid arthritis
small molecule
TNF trimer
immunogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1037983/full
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https://www.frontiersin.org/articles/10.3389/fphar.2022.1037983/full

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