Decreased plasma nicotinamide and altered NAD+ metabolism in glial cells surrounding Aβ plaques in a mouse model of Alzheimer's disease

Decreased plasma nicotinamide and altered NAD+ metabolism in glial cells surrounding Aβ plaques in a mouse model of Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disease and a leading cause of senile dementia. Amyloid-β (Aβ) accumulation triggers chronic neuroinflammation, initiating AD pathogenesis. Recent clinical trials for anti-Aβ immunotherapy underscore that blood-based biomarkers have si...

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Bibliographic Details
Main Authors: Michiko Sekiya, Yasufumi Sakakibara, Yu Hirota, Naoki Ito, Sachie Chikamatsu, Kimi Takei, Risa Nishijima, Koichi M. Iijima
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease (AD)
Amyloid-β (Aβ)
Metabolomic analysis
App knock-in mouse
Nicotinamide
NAD+
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124002948
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