Ribosomal protein L5 induces cellular senescence via p53-p21-pRb pathway to mediate relapse of acute myeloid leukemia

Ribosomal protein L5 induces cellular senescence via p53-p21-pRb pathway to mediate relapse of acute myeloid leukemia

Abstract Cellular senescence plays a critical role in the relapse of acute myeloid leukemia (AML), yet the underlying mechanisms remain incompletely understood. Here, we investigated the function of ribosomal protein L5 (RPL5) in mediating cellular senescence and its impact on AML relapse. In relaps...

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Bibliographic Details
Main Authors: Wanqiu Zhang, Linlin Liu, Ruotong Chen, Haotian Yan, Qing Zhang, Xiyang Ren, Huiping Wang, Yi Dong, Wanying Xue, Zhimin Zhai, Qianshan Tao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Acute myeloid leukemia
Relapse
Cellular senescence
Ribosome stress
Ribosomal protein L5
Online Access:https://doi.org/10.1038/s41598-025-12108-1
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https://doi.org/10.1038/s41598-025-12108-1

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