Development of a physiologically based pharmacokinetic model of fostemsavir and its pivotal application to support dosing in pregnancy

Development of a physiologically based pharmacokinetic model of fostemsavir and its pivotal application to support dosing in pregnancy

Abstract It is critical to understand the impact of significant physiological changes during pregnancy on the extent of maternal and fetal drug exposure. Fostemsavir (FTR) is a prodrug of temsavir (TMR) and is approved in combination with other antiretrovirals for multi‐drug‐resistant human immunode...

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Bibliographic Details
Main Authors: Farzaneh Salem, Dung Nguyen, Mark Bush, Katy P. Moore, Jennypher Mudunuru, Konstantinos Stamatopoulos, Nilay Thakkar, Kunal S. Taskar
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13156
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