Effects of 17β-estradiol and equilin on atherosclerosis development in female Apoe shl mice

Effects of 17β-estradiol and equilin on atherosclerosis development in female Apoe shl mice

Abstract The effects of conjugated equine estrogens (CEE) and 17β-estradiol-based hormone replacement therapy (HRT) on atherosclerosis development remain controversial. Here, we investigated the effects of equilin, a major compound in CEE, and 17β-estradiol on atherosclerosis development in an ather...

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Main Authors: Akiyo Kakibuchi, Fumitake Ito, Osamu Takaoka, Nanami Tahara, Mari Kawamata, Kazuya Yabumoto, Akihisa Katayama, Yuko Izumi, Eiko Maeda, Taisuke Mori
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hormone replacement therapy (HRT)
Atherosclerosis
Estrogen
Equilin
En face analysis
Aortic root analysis
Online Access:https://doi.org/10.1038/s41598-025-10494-0
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https://doi.org/10.1038/s41598-025-10494-0

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