Phosphorylation of Ser711 residue in the hypervariable region of zoonotic genotype 3 hepatitis E virus is important for virus replication

Phosphorylation of Ser711 residue in the hypervariable region of zoonotic genotype 3 hepatitis E virus is important for virus replication

ABSTRACT Hepatitis E virus (HEV) is distinct from other hepatotropic viruses because it is zoonotic. HEV-1 and HEV-2 exclusively infect humans, whereas HEV-3 and HEV-4 are zoonotic. However, the viral and/or host factors responsible for cross-species HEV transmission remain elusive. The hypervariabl...

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Main Authors: Bo Wang, Sakthivel Subramaniam, Debin Tian, Hassan M. Mahsoub, C. Lynn Heffron, Xiang-Jin Meng
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
hepatitis E virus (HEV)
HEV-3
zoonotic infection
hypervariable region (HVR)
phosphorylation
mutagenesis
Online Access:https://journals.asm.org/doi/10.1128/mbio.02635-24
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https://journals.asm.org/doi/10.1128/mbio.02635-24

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