Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan

Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan

Recent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology. Among them, Lysosome-Targeting Chimeras (LYTACs) acting through mannose 6-phosphate receptor...

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Bibliographic Details
Main Authors: Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
bisM6P-conjugated antibody
CI-MPR
LYTAC
M6P
protein degradation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2415333
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