Directed evolution and modular integration of a high-affinity ICOS-L variant for potent T cell–mediated tumor elimination

Directed evolution and modular integration of a high-affinity ICOS-L variant for potent T cell–mediated tumor elimination

Abstract Background Advancing cancer immunotherapy requires engineering synthetic immunomodulators that integrate precise receptor targeting, tunable activity, and compatibility with modular biologic formats. The Inducible T-cell Co-Stimulator (ICOS) is a clinically validated co-stimulatory receptor...

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Bibliographic Details
Main Authors: Ji Yeon Ha, Tae Wook Song, Petrina Jebamani, Sun-Gu Lee, Sang Taek Jung
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Biological Engineering
Subjects:
ICOS-L
T-cell co-stimulation
Immune checkpoint fusion
Directed evolution
Synthetic Immunomodulator
Modular biologics
Online Access:https://doi.org/10.1186/s13036-025-00536-6
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https://doi.org/10.1186/s13036-025-00536-6

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