Comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban in dogs

Comparison of the pharmacokinetics and pharmacodynamics of apixaban and rivaroxaban in dogs

Abstract Background Comparative pharmacokinetics and pharmacodynamics (PK/PD) of apixaban and rivaroxaban have not been studied in dogs and the propensity of these drugs to cause hypercoagulability after discontinuation is unknown. Hypothesis Compare the PK/PD of clinical dosing regimens of PO apixa...

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Bibliographic Details
Main Authors: Alex M. Lynch, Laura K. Ruterbories, Yao Zhu, Frank Fialkiewicz, Mark G. Papich, Marjory B. Brooks, Robert Goggs
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Journal of Veterinary Internal Medicine
Subjects:
anticoagulant
anti‐Xa
direct oral anticoagulant
DOAC
thrombin generation
thromboprophylaxis
Online Access:https://doi.org/10.1111/jvim.17216
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https://doi.org/10.1111/jvim.17216

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