Mechanisms underlying delayed loss of HBeAg and HBV DNA following HBsAg seroclearance in PEG-IFNα treated patients of chronic hepatitis B

Mechanisms underlying delayed loss of HBeAg and HBV DNA following HBsAg seroclearance in PEG-IFNα treated patients of chronic hepatitis B

Background & Aims A notable proportion of CHB patients undergoing PEG-IFNα based therapy experience lagged serum HBeAg and/or HBV DNA disappearance in patients achieving HBsAg loss. In this study, we explored the molecular mechanisms behind this clinical phenomenon, offering novel insights into...

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Main Authors: Bei Jiang, Guiwen Guan, Kaitao Zhao, Zhiqiang Gu, Lin Wang, Weilin Gu, Minghui Li, Yuchen Xia, Xiangmei Chen, Yifei Guo, Jiming Zhang, Zhenhuan Cao, Man-fung Yuen, Fengmin Lu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Hepatitis B virus
PEGylated interferon alpha
Hepatitis B surface antigen seroclearance
Pres1and preS2 promoters
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2475847
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https://www.tandfonline.com/doi/10.1080/22221751.2025.2475847

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