A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties
Bone graft absorption and infection are the major challenges to guided bone regeneration(GBR), yet the GBR membrane is neither osteogenic nor antibacterial. Hence, we followed sono-piezo therapy strategy by fabricating an electrospun membrane dispersed with boron nitride nanotubes. The PLLA/Gelatine...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
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| Series: | Materials Today Bio |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004794 |
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| Summary: | Bone graft absorption and infection are the major challenges to guided bone regeneration(GBR), yet the GBR membrane is neither osteogenic nor antibacterial. Hence, we followed sono-piezo therapy strategy by fabricating an electrospun membrane dispersed with boron nitride nanotubes. The PLLA/Gelatine/PDA@BNNT (PGBT) membrane has improved mechanical and biocompatible properties and generate piezovoltages of 130 mV when activated by ultrasound stimulation under 100 mW/cm2 without extra polarization. The PGBT with ultrasound is conducive to cellular osteogenesis, barrier function, and shows antibacterial rate of about 40 %. The rat cranial defect experiments revealed that PGBT with ultrasound could promote osteogenesis in-vivo and show great potentials for vertical bone defect repair. |
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| ISSN: | 2590-0064 |