In vitro co-culture of Fasciola hepatica newly excysted juveniles (NEJs) with 3D HepG2 spheroids permits novel investigation of host–parasite interactions

In vitro co-culture of Fasciola hepatica newly excysted juveniles (NEJs) with 3D HepG2 spheroids permits novel investigation of host–parasite interactions

Fasciola hepatica, or liver fluke, causes fasciolosis in humans and livestock. Following ingestion of vegetation contaminated with encysted parasites, metacercariae, newly excysted juveniles (NEJ) excyst in the small intestine and cross the intestinal wall. After penetrating the liver, the parasite...

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Bibliographic Details
Main Authors: Aiste Vitkauskaite, Emma McDermott, Richard Lalor, Carolina De Marco Verissimo, Mahshid H. Dehkordi, Kerry Thompson, Peter Owens, Howard Oliver Fearnhead, John Pius Dalton, Nichola Eliza Davies Calvani
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Virulence
Subjects:
Fasciola hepatica
liver fluke
HepG2
spheroids
3D cell culture
helminth
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2025.2482159
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