Combined immunotherapy with nivolumab and ipilimumab with and without local therapy in patients with melanoma brain metastasis: a DeCOG* study in 380 patients

Combined immunotherapy with nivolumab and ipilimumab with and without local therapy in patients with melanoma brain metastasis: a DeCOG* study in 380 patients

Background Nivolumab combined with ipilimumab have shown activity in melanoma brain metastasis (MBM). However, in most of the clinical trials investigating immunotherapy in this subgroup, patients with symptomatic MBM and/or prior local brain radiotherapy were excluded. We studied the efficacy of ni...

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Main Authors: Carola Berking, Jessica C Hassel, Lisa Zimmer, Ralf Gutzmer, Teresa Amaral, Thomas Eigentler, Claus Garbe, Julia Tietze, Thilo Gambichler, Patrick Terheyden, Felix Kiecker, Sarah Schaefer, Henner Stege, Katharina Kaehler, Sebastian Haferkamp, Jochen Uttikal, David Rafei-Shamsabadi, Lydia Reinhardt, Friedegund Meier, Ante Karoglan, Christian Posch, Claudia Pfoehler, Kai Thoms, Dirk Debus, Rudolf Herbst, Steffen Emmert, Carmen Loquai, Frank Meiss, Thomas Tueting, Vanessa Heinrich
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000333.full
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