Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival

Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival

Abstract Objectives Langerhans cells (LCs) are epithelial antigen‐presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechanisms of alteration of IL34 and LC function in squamous cell carcinoma (S...

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Bibliographic Details
Main Authors: Thi Viet Trinh Dang, Kevin R Gillinder, Quan Nguyen, Onkar Mulay, Tuan Vo, Ahmed M Mehdi, Chenhao Zhou, Andrew J Brooks, Graham R Leggatt, David A Hume, Ian H Frazer, Janin Chandra
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Clinical & Translational Immunology
Subjects:
epithelial hyperplasia
IL34
Langerhans cells
squamous cell carcinoma
Online Access:https://doi.org/10.1002/cti2.70018
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https://doi.org/10.1002/cti2.70018

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