Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice

Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice

Abstract Membrane-initiated estrogen receptor α (mERα) signaling has been shown to affect bone mass in murine models. However, it remains unknown which cell types mediate the mERα-dependent effects on bone. In this study, we generated a novel mouse model with a conditional C451A mutation in Esr1, wh...

Full description

Saved in:
Bibliographic Details
Main Authors: Yiwen Jiang, Karin Horkeby, Petra Henning, Jianyao Wu, Karin H. Nilsson, Lina Lawenius, Sofia Movérare-Skrtic, Priti Gupta, Cecilia Engdahl, Antti Koskela, Juha Tuukkanen, Lei Li, Claes Ohlsson, Marie K. Lagerquist
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-025-00439-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41413-025-00439-8

Similar Items