Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats

Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats

Abstract Background Complex perianal fistulas, challenging to treat and prone to recurrence, often require surgical intervention that may cause fecal incontinence and lower quality of life due to large surgical wounds and potential sphincter damage. Human umbilical cord-derived MSCs (hUC-MSCs) and t...

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Main Authors: Yafei Lu, Shaohua Huangfu, Chuanxue Ma, Yan Ding, Yajie Zhang, Chungen Zhou, Lianming Liao, Ming Li, Jia You, Yuting Chen, Dawei Wang, Ao Chen, Bin Jiang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Stem Cell Research & Therapy
Subjects:
Exosomes derived from umbilical cord mesenchymal stem cells
Complex perianal fistulas
Wound healing
HIF-1α
TGF-β/Smad signaling pathway
Online Access:https://doi.org/10.1186/s13287-024-04028-0
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https://doi.org/10.1186/s13287-024-04028-0

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