PFKFB3-dependent redox homeostasis and DNA repair support cell survival under EGFR-TKIs in non-small cell lung carcinoma

PFKFB3-dependent redox homeostasis and DNA repair support cell survival under EGFR-TKIs in non-small cell lung carcinoma

Abstract Background The efficacy of tyrosine kinase inhibitors (TKIs) targeting the EGFR is limited due to the persistence of drug-tolerant cell populations, leading to therapy resistance. Non-genetic mechanisms, such as metabolic rewiring, play a significant role in driving lung cancer cells into t...

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Bibliographic Details
Main Authors: Nadiia Lypova, Susan M. Dougherty, Brian F. Clem, Jing Feng, Xinmin Yin, Xiang Zhang, Xiaohong Li, Jason A. Chesney, Yoannis Imbert-Fernandez
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer & Metabolism
Subjects:
Non-small cell lung carcinoma
EGFR
PFKFB3
GPX4
Oxidative stress
Base excision DNA repair
Online Access:https://doi.org/10.1186/s40170-024-00366-y
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https://doi.org/10.1186/s40170-024-00366-y

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