PIVKA-II but not dp-ucMGP is associated with aortic calcification in chronic kidney disease

PIVKA-II but not dp-ucMGP is associated with aortic calcification in chronic kidney disease

Abstract Background Patients with chronic kidney disease (CKD) are susceptible to vascular calcification and vitamin K deficiency. Matrix gla protein (MGP) is a potent inhibitor of calcification requiring vitamin K for activation. Inactive MGP, i.e. dephosphorylated uncarboxylated MGP (dp-ucMGP), is...

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Main Authors: Jakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Bjarne Linde Nørgaard, Jonna Skov Madsen, Sebastian Nielsen, Martin Bjergskov Thomsen, Jesper Møller Jensen, Christian Daugaard Peters, Niels Henrik Buus
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Nephrology
Subjects:
Atherosclerosis
Chronic kidney disease
Vitamin K dependent proteins
Aorta
Calcification
Ageing
Online Access:https://doi.org/10.1186/s12882-024-03876-5
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https://doi.org/10.1186/s12882-024-03876-5

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