HDACi combination therapy with IDO1i remodels the tumor microenvironment and boosts antitumor efficacy in colorectal cancer with microsatellite stability

HDACi combination therapy with IDO1i remodels the tumor microenvironment and boosts antitumor efficacy in colorectal cancer with microsatellite stability

Abstract Background Immunotherapy for colorectal cancer (CRC) with microsatellite stability (MSS) and mismatch repair proficiency (pMMR) has shown limited success in clinical trials. The combination of immunomodulators and immune checkpoint inhibitors (ICIs) is a potential strategy for treating CRC....

Full description

Saved in:
Bibliographic Details
Main Authors: Rongpu Liang, Dongbing Ding, Yiquan Li, Tianyun Lan, Svetlana Ryabtseva, Shengxin Huang, Jiannan Ren, He Huang, Bo Wei
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
IDO1
HDAC
Colorectal cancer
Tumor microenvironment
Microsatellite stability
Online Access:https://doi.org/10.1186/s12951-024-02936-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12951-024-02936-0

Similar Items