CDX1 improves nicotine induced cardiac fibroblasts activation and cardiomyocyte hypertrophy by alleviating autophagic flux impairment through modulation of LAPTM4B

CDX1 improves nicotine induced cardiac fibroblasts activation and cardiomyocyte hypertrophy by alleviating autophagic flux impairment through modulation of LAPTM4B

Abstract Nicotine-induced impairment of autophagic flux promotes the onset of myocardial remodelling, thereby exacerbating heart failure. In this study, we investigated the role and molecular mechanisms of the transcription factor CDX1 in cardiac fibroblasts (CFs) activation and cardiomyocyte hypert...

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Main Authors: Yue-yan Li, Fan-liang Meng, Si-yuan Zhou, Jia-min Du, Wen-jing Li, Qi-yun Liu, Lei Wu, Meng-meng Zhao, Yi Jin, Qun-ye Zhang, Ying Li, Guo-hai Su
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
CDX1
LAPTM4B
Autophagic flux
Nicotine
Cardiomyocyte hypertrophy
Fibroblast activation
Online Access:https://doi.org/10.1038/s41598-025-94160-5
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https://doi.org/10.1038/s41598-025-94160-5

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