Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway

Atractylenolide I Inhibits Nicotine-Induced Macrophage Pyroptosis and Alleviates Atherogenesis by Suppressing the TLR4/ROS/TXNIP/NLRP3 Pathway

<b>Background/Objectives:</b> Studies have shown that Atractylenolide I (AT-I) can exert anti-inflammatory and anti-oxidative effects, protecting against the development of various kinds of cardiovascular diseases. However, whether AT-I prevents nicotine-induced atherogenesis is unknown....

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Bibliographic Details
Main Authors: Huan-Huan Li, Xian Liu, Yu-Ping Wang, Xi Xu, Lin Zhu, Wei Zhang, Kun Ren
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Metabolites
Subjects:
Atractylenolide I
nicotine
macrophage
pyroptosis
atherosclerosis
Online Access:https://www.mdpi.com/2218-1989/15/5/329
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