PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer

PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer

Abstract Background Colorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response. Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) exhibits intricate implications in tumorigenesis and progression. Nevertheless...

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Main Authors: Mingzhou Li, Jianbiao Xiao, Shasha Song, Fangyi Han, Hongling Liu, Yang Lin, Yunfei Ni, Sisi Zeng, Xin Zou, Jieqiong Wu, Feifei Wang, Shaowan Xu, You Liang, Peishuang Xu, Huirong Hong, Junfeng Qiu, Jianing Cao, Qin Zhu, Li Liang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Medicine
Subjects:
Colorectal cancer
PREX2
Immunogenic cell death
Radioresistance
cGAS/STING/IFNs
Online Access:https://doi.org/10.1186/s12916-024-03375-2
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https://doi.org/10.1186/s12916-024-03375-2

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