Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious

Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious

Abstract Flavivirus assembly is driven by the envelope glycoproteins pre-membrane (prM) and envelope (E) in the neutral pH environment of the endoplasmic reticulum. Newly budded, spiky particles are exported through the Golgi apparatus, where mildly acidic pH induces a major surface rearrangement. T...

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Main Authors: Jiří Holoubek, Jiří Salát, Milos Matkovic, Petr Bednář, Pavel Novotný, Martin Hradilek, Taťána Majerová, Ebba Rosendal, Luděk Eyer, Andrea Fořtová, Michaela Beránková, Lesley Bell-Sakyi, Anna K. Överby, Andrea Cavalli, Massimiliano Bonomi, Félix A. Rey, Daniel Růžek
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62750-6
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https://doi.org/10.1038/s41467-025-62750-6

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