NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas

NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas

The neurotrophic tyrosine kinase receptor (NTRK) gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins. Pan-TRK antibody, which shows the overexpression of the NTRK1-2-3 genes, is a useful tool to detect tumors wit...

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Bibliographic Details
Main Authors: Zoltán Lippai, Gergő Papp, Károly Szuhai, Johanna Sápi, Katalin Dezső, Zoltán Sápi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Pathology and Oncology Research
Subjects:
soft tissue sarcoma
dedifferentiated liposarcoma
gene rearrangement
gene amplification
NTRK
Online Access:https://www.por-journal.com/articles/10.3389/pore.2024.1611993/full
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