Detection of oncogenic fusions in colorectal cancer using a partner-agnostic next-generation sequencing approach

Detection of oncogenic fusions in colorectal cancer using a partner-agnostic next-generation sequencing approach

Abstract Background Gene fusions exist with low prevalence in colorectal cancer (CRC), and the clinical utility of fusion testing in advanced CRC remains unclear. We sought to identify oncogenic fusions in patients with advanced CRC using a fusion partner-agnostic circulating tumor DNA (ctDNA) assay...

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Main Authors: Andrew J. Pellatt, Reagan M. Barnett, Sante Gnerre, Kristin Edwards, Jason A. Willis, Michael J. Overmann, Kanwal Raghav, Christine M. Parseghian, Arvind Dasari, M. Pia Morelli, Alisha Bent, Madhulika Eluri, Nicholas Hornstein, Leylah M. Drusbosky, Scott Kopetz, Van K. Morris
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Fusion
EGFR
ctDNA
Online Access:https://doi.org/10.1186/s12885-025-14117-9
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https://doi.org/10.1186/s12885-025-14117-9

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