Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial

Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial

Abstract Pediatric major depressive disorder (MDD) represents a leading cause of disability worldwide in children and adolescents, while its underlying pathophysiology remains largely elusive. The endocannabinoid system (ECS) and the hypothalamus-pituitary-adrenal (HPA) axis are considered intertwin...

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Main Authors: Andreas Walther, Lukas Eggenberger, Rudolf Debelak, Clemens Kirschbaum, Isabelle Häberling, Ester Osuna, Michael Strumberger, Susanne Walitza, Jeannine Baumgartner, Isabelle Herter-Aeberli, Gregor Berger
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03401-8
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https://doi.org/10.1038/s41398-025-03401-8

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