A Role for PPAR𝛽/𝛿 in Ocular Angiogenesis
The uses of highly selective PPAR𝛽/𝛿 ligands and PPAR𝛽/𝛿 knockout mice have shown a direct ability of PPAR𝛽/𝛿 to regulate angiogenesis in vitro and in vivo in animal models. PPAR𝛽/𝛿 ligands induce the proangiogenic growth factor VEGF in many cells and tissues, though its actions in the eye are not k...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/825970 |
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| Summary: | The uses of highly selective PPAR𝛽/𝛿 ligands and PPAR𝛽/𝛿 knockout mice have shown a direct ability of PPAR𝛽/𝛿 to regulate angiogenesis in vitro and in vivo in animal models. PPAR𝛽/𝛿 ligands induce the proangiogenic growth factor VEGF in many cells and tissues, though its actions in the eye are not known. However, virtually, all tissue components of the eye express PPAR𝛽/𝛿. Both angiogenesis and in particular VEGF are not only critical for the development of the retina, but they are also a central component in many common pathologies of the eye, including diabetic retinopathy and age-related macular degeneration, the most common causes of blindness in the Western world. This review, therefore, will discuss the recent evidence of PPAR𝛽/𝛿-mediated angiogenesis and VEGF release in the context of ocular disorders. |
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| ISSN: | 1687-4757 1687-4765 |