Skeletal muscle proteome differs between young APOE3 and APOE4 targeted replacement mice in a sex-dependent manner

Skeletal muscle proteome differs between young APOE3 and APOE4 targeted replacement mice in a sex-dependent manner

IntroductionApolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele mediates risk. APOE4 carriers experience reduced mobility and faster decline in muscle strength, suggesting skeletal muscle involvement. Mitochondria ar...

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Bibliographic Details
Main Authors: Chelsea N. Johnson, Colton R. Lysaker, Colin S. McCoin, Mara R. Evans, John P. Thyfault, Heather M. Wilkins, Jill K. Morris, Paige C. Geiger
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
APOE4
Alzheimer's disease
skeletal muscle
mitochondria
proteomics
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1486762/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2024.1486762/full

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